Immunohistochemical identification of notochordal markers in cells in the aging human lumbar intervertebral disc

Prolapsed Lumbar Intervertebral Disc

Cramps in the affected leg are quite common and persistent although sciatic pain may have disappeared completely. A small proportion of patients develop a true recurrent prolapse (prolapse from the same disc) months to years later. This varies in individual statistics, but is probably in the neighbourhood of 4 per cent. to 5 per cent. These recurrent attacks of sciatica, due to a further protru...

Herniated intervertebral lumbar disc in the teenager.

Activation of intervertebral disc cells by co-culture with notochordal cells, conditioned medium and hypoxia

BACKGROUND Notochordal cells (NC) remain in the focus of research for regenerative therapy for the degenerated intervertebral disc (IVD) due to their progenitor status. Recent findings suggested their regenerative action on more mature disc cells, presumably by the secretion of specific factors, which has been described as notochordal cell conditioned medium (NCCM). The aim of this study was to...

Potential application of notochordal cells for intervertebral disc regeneration: an in vitro assessment.

Recent studies suggest that notochordal cells (NCs) might be involved in intervertebral disc homeostasis, a role exploitable to counteract matrix degradation as observed during degeneration. This study aimed to evaluate the potential of NCs to promote matrix production by nucleus pulposus cells (NPCs) and to compare it to the currently proposed addition of bone marrow stromal cells (BMSCs). Usi...

Effects of Morphine Dependency on Intervertebral Disc in the Rat

Background: A large proportion of patients presenting with lumbar disc disease are opium addicts in our region. It was, therefore, hypothesized that morphine might affect the intervertebral disc. We investigated the histological findings of morphine dependency on intervertebral discs in rat. Methods: Forty NMRI adult male rats (230-250 g) placed on ordinary diet and received aqueous solution of...